Self‐assembly of thiolated versus non‐thiolated peptide amphiphiles

Peptide based amphiphiles.

Peptide Amphiphiles in Corneal Tissue Engineering

The increasing interest in effort towards creating alternative therapies have led to exciting breakthroughs in the attempt to bio-fabricate and engineer live tissues. This has been particularly evident in the development of new approaches applied to reconstruct corneal tissue. The need for tissue-engineered corneas is largely a response to the shortage of donor tissue and the lack of suitable a...

Morphological characterization of self-assembled peptide nucleic acid amphiphiles.

Peptide nucleic acid amphiphiles (PNAA) are a promising set of materials for sequence-specific separation of nucleic acids from complex mixtures. To implement PNAA in micellar separations, the morphology and size of PNAA micelles in the presence and absence of a sodium dodecyl sulfate (SDS) cosurfactant have been studied by small-angle X-ray scattering and dynamic light scattering. We find that...

The internal structure of self-assembled peptide amphiphiles nanofibers{

The self-assembly of peptide amphiphiles (PAs) into nanofibers and their bioactivity as well as physical properties have been investigated by our laboratory over the past few years. We report here on the use of transmission infrared spectroscopy (IR) and polarization modulation-infrared reflection-absorption spectroscopy (PM-IRRAS) to characterize the internal structure of the nanofibers. Depos...

Self-assembly of model DNA-binding peptide amphiphiles.

Peptide amphiphiles combine the specific functionality of proteins with the engineering convenience of synthetic amphiphiles. These molecules covalently link a peptide headgroup, typically from an active fragment of a larger protein, to a hydrophobic alkyl tail. Our research is aimed at forming and characterizing covalently stabilized, self-assembled, peptide-amphiphile aggregates that can be u...